中文名 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE |
英文名 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE |
别名 | 多肽T H-ALA-SER-THR-THR-THR-ASN-TYR-THR-OH |
英文别名 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate salt L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl- L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)- |
CAS | 106362-32-7 |
化学式 | C35H55N9O16 |
分子量 | 857.86 |
存储条件 | -20°C |
体外研究 | Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4. Peptide T at 10 -8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10 -9 M concentration significantly inhibits IFN-g production by PBMC. |
体内研究 | Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE. |
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